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KMID : 0363020090390030349
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Journal of Korean Academy of Periodontology
2009 Volume.39 No. 3 p.349 ~ p.358
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The effect of the freeze dried bone allograft and gel/putty type demineralized bone matrix n osseous regeneration in the rat calvarial defects
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Kim Deug-Han
Pang Eun-Kyoung
Hong Ji-Youn
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Abstract
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Purpose: This study was aimed to evaluate the effect of the Freeze Dried Bone Allograft and Demineralized Bone Matrix on osseous regeneration in the rat calvarial defects.
Methods: Eight mm critical-sized calvarial defects were created in the 80 male Sprague-Dawley rats. The animals were divided into 4 groups of 20 animals each. The defects were treated with Freeze Dried Bone Allograft(SureOss TM ), Demineralized Bone Matrix(ExFuse TM Gel, ExFuse TM Putty), or were left untreated for sham-surgery control and were evaluated by histologic and histomorphometric parameters following a 2 and 8 week healing intervals. Statistical analysis was done between each groups and time intervals with ANOVA and paired t-test.
Results: Defect closure, New bone area, Augmented area in the SureOss TM , ExFuse TM Gel, ExFuse TM Putty groups were significantly greater than in the sham-surgery control group at each healing interval(P < 0.05). In the New bone area and Defect closure, there were no significant difference between experimental groups. Augmented area in the ExFuse TM Gel, ExFuse TM Putty groups were significantly greater than SureOss TM group at 2weeks(P < 0.05), however there was no significant difference at 8 weeks.
Conclusions: All of SureOss TM , ExFuse TM Gel, ExFuse TM Putty groups showed significant new bone formation and augmentation in the calvarial defect model.
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KEYWORD
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alveolar bone Loss, bone regeneration, bone transplantation, transplantation, homologous
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